Rigorous by design
A structured, repeatable methodology that turns a fragmented evidence base into conclusions you can defend.
A single substance may be described in a REACH dossier, an ATSDR profile, an IARC monograph, EPA screening data, and hundreds of peer-reviewed studies, and those sources don't always agree. Other substances have almost no data at all. Searching the literature is straightforward. Searching it completely, weighing it correctly, and filling gaps defensibly is the discipline we bring.
Five steps to a defensible answer
Establish substance identity
We confirm CAS and EC numbers, synonyms, trade names, composition, and impurity profile. Accurate identification is the foundation of every sound assessment, and of any valid read-across.
Search comprehensively
Each engagement follows a standardized endpoint checklist applied across every relevant public and licensed source, ensuring consistent and complete coverage.
Fill data gaps with read-across
Where substance-specific data is missing, we identify suitable analogues or chemical categories and apply read-across in line with ECHA's Read-Across Assessment Framework and OECD guidance on grouping of chemicals.
Reconcile and weigh the evidence
Where findings diverge, we document the divergence and explain which evidence carries greater scientific and regulatory weight, and why.
Deliver focused conclusions
You receive an answer to your question, not an unfiltered literature compilation. Every statement is referenced to its source and date of access, and every read-across is identified as such.
When data is missing, we don't guess
Many substances in commerce have never been fully tested. Read-across is the scientifically recognized way to address this: data from structurally and mechanistically similar substances is used to predict the properties of the substance in question. Regulators, including ECHA, accept it when it is properly justified.
We document every read-across in full: the analogues selected, the structural and mechanistic basis for similarity, the data carried across, and an explicit statement of uncertainty. You and any reviewer can judge its strength for yourselves.
Similarity is established on structure, physicochemical properties, metabolism, and mode of action, not structure alone.
An analytical firm, by deliberate choice
ChemVigil doesn't perform laboratory testing. This independence is intentional. With no stake in any study outcome, our sole interest is an accurate and impartial reading of the evidence.
Our quality standards
- Standardized templates and endpoint checklists
- Full referencing with access dates
- Documented justification for every read-across
- Independent second review of every deliverable
- Version-controlled reports for complete traceability
- Clear statement of confidence and data gaps in every report
Reports built for the people who have to act on them
Executive summary first
The conclusions, the confidence we place in them, and the actions they imply, on the first page. The supporting detail follows for those who need it.
A complete source register
Every source consulted, whether or not it changed the conclusion, listed with its version and date of access so the analysis can be reproduced.
A briefing, not just a document
Every engagement closes with a walkthrough of the findings, so your team leaves with answers rather than a reading assignment.
See our methodology applied to your substance
Share the chemical and your timeline. We'll scope the work in a single conversation.
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